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The neutrophil in vascular inflammation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
2011 (English)In: Nature Medicine, ISSN 1078-8956, Vol. 17, no 11, 1381-1390 p.Article, review/survey (Refereed) Published
Abstract [en]

Here we focus on how neutrophils have a key regulatory role in vascular inflammation. Recent studies using advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these processes may be disrupted in systemic infections, with a particular emphasis on mouse models of sepsis. Neutrophils are often immobilized in the lungs and liver during systemic infections, and this immobilization may be a mechanism through which bacteria can evade the innate immune response or allow neutrophils to form neutrophil extracellular traps that trap and kill bacteria in blood. The platelet is also an important player in sepsis, and we describe how it collaborates with neutrophils in the formation of neutrophil extracellular traps.

Place, publisher, year, edition, pages
2011. Vol. 17, no 11, 1381-1390 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-162613DOI: 10.1038/nm.2514ISI: 000296779300029OAI: oai:DiVA.org:uu-162613DiVA: diva2:461554
Available from: 2011-12-05 Created: 2011-12-02 Last updated: 2011-12-05Bibliographically approved

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