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Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
University of New Mexico.
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2011 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 6, no 11, e28366- p.Article in journal (Refereed) Published
Abstract [en]

FusE mutants are fusidic acid-resistant small colony variants (SCVs) of Staphylococcus aureus that can be selected with aminoglycosides. All FusE SCVs have mutations in rplF, encoding ribosomal protein L6. However, individual FusE mutants including some with the same mutation in rplF display auxotrophy for either hemin or menadione, suggesting that additional mutations are involved. Here we show that FusE SCVs can be divided into three genetic sub-groups and that some carry an additional mutation, in one of the genes required for hemin biosynthesis, or in one of the genes required for menadione biosynthesis. Reversion analysis and genome sequencing support the hypothesis that these combinations of mutations in the rplF, hem, and/or men genes can account for the SCV and auxotrophic phenotypes of FusE mutants.

Place, publisher, year, edition, pages
2011. Vol. 6, no 11, e28366- p.
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Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-162905DOI: 10.1371/journal.pone.0028366ISI: 000298166300050PubMedID: 22140579OAI: oai:DiVA.org:uu-162905DiVA: diva2:461979
Available from: 2011-12-06 Created: 2011-12-06 Last updated: 2017-12-08Bibliographically approved

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Cao, ShaHughes, Diarmaid

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