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Macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues. In vivo study in nude mice.
Inst för Experimentell och Klinisk medicin, Linköping.ORCID iD: 0000-0002-9735-1434
Inst för Experimentell och Klinisk medicin, Linköping.
Inst för Experimentell och Klinisk medicin, Linköping.
Inst för Experimentell och Klinisk medicin, Linköping.
2007 (English)In: Journal of Plastic, Reconstructive & Aesthetic Surgery, ISSN 1748-6815, E-ISSN 1532-1959, Vol. 60, no 5, 543-55 p.Article in journal (Refereed) Published
Abstract [en]

In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermally in nude mice gelatine spheres that had either been preseeded with human fibroblasts or preadipocytes, or left unseeded. We compared the extent of regenerated tissue with that found after injections of saline or single-cell suspensions of human fibroblasts or preadipocytes. Routine histological examinations and immunohistochemical staining for von Willebrand factor (indicating neoangiogenesis) were made after 7, 21, and 56 days. Injected saline or single-cell suspensions had no effect. However, a quick and thorough tissue regeneration with developing neoangiogenesis was elicited by the gelatine spheres and the effect of spheres preseeded with preadipocytes surpassed the effect of spheres preseeded with fibroblasts, which in turn surpassed the effect of unseeded gelatine spheres. We suggest that minor soft tissue defects such as wrinkles or creases can be corrected by injection of naked macroporous gelatine spheres, whereas larger defects are best corrected by injection of macroporous gelatine spheres preseeded with fibroblasts, or preadipocytes, or both.

Place, publisher, year, edition, pages
2007. Vol. 60, no 5, 543-55 p.
National Category
Cell and Molecular Biology Surgery
Identifiers
URN: urn:nbn:se:uu:diva-162776DOI: 10.1016/j.bjps.2005.10.031PubMedID: 17399665OAI: oai:DiVA.org:uu-162776DiVA: diva2:462021
Available from: 2011-12-06 Created: 2011-12-05 Last updated: 2017-12-08
In thesis
1. In vitro and in vivo studies of tissue engineering in reconstructive plastic surgery
Open this publication in new window or tab >>In vitro and in vivo studies of tissue engineering in reconstructive plastic surgery
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Linköping: Unitryck, 2005. 75 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 905
National Category
Surgery
Research subject
Plastic Surgery
Identifiers
urn:nbn:se:uu:diva-286421 (URN)91-85299-06-5 (ISBN)
Public defence
2005-09-02, Linköping, 14:43 (English)
Opponent
Supervisors
Available from: 2016-04-22 Created: 2016-04-20 Last updated: 2016-04-22Bibliographically approved

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Huss, Fredrik R M

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