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Characterization of a new degradable polymer scaffold for regeneration of the dermis: In vitro and in vivo human studies.
Inst för Experimentell och Klinisk medicin, Linköping.ORCID iD: 0000-0002-9735-1434
Inst för Experimentell och Klinisk medicin, Linköping.
Kirurgiska vetenskaper, KI.
Artimplant AB.
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2008 (English)In: Organogenesis, ISSN 1547-6278, Vol. 4, no 3, 195-200 p.Article in journal (Refereed) Published
Abstract [en]

Full thickness skin wounds in humans heal with scars, but without regeneration of the dermis. A degradable poly(urethane urea) scaffold (PUUR), Artelon(R) is already used to reinforce soft tissues in orthopaedics, and for treatment of osteoarthritis of the hand, wrist and foot. In this paper we have done in vitro experiments followed by in vivo studies to find out whether the PUUR is biocompatible and usable as a template for dermal regeneration. Human dermal fibroblasts were cultured on discs of PUUR, with different macrostructures (fibrous and porous). They adhered to and migrated into the scaffolds, and produced collagen. The porous scaffold was judged more suitable for clinical applications and 4 mm Ø, 2 mm-thick discs of porous scaffold (12% w/w or 9% w/w polymer solution) were inserted intradermally in four healthy human volunteers. The implants were well tolerated and increasing ingrowth of fibroblasts was seen over time in all subjects. The fibroblasts stained immunohistochemically for procollagen and von Willebrand factor, indicating neocollagenesis and angiogenesis within the scaffolds. The PUUR scaffold may be a suitable material to use as a template for dermal regeneration.

Place, publisher, year, edition, pages
2008. Vol. 4, no 3, 195-200 p.
National Category
Cell and Molecular Biology Surgery
Identifiers
URN: urn:nbn:se:uu:diva-162772PubMedID: 19279733OAI: oai:DiVA.org:uu-162772DiVA: diva2:462028
Available from: 2011-12-06 Created: 2011-12-05 Last updated: 2016-04-22
In thesis
1. In vitro and in vivo studies of tissue engineering in reconstructive plastic surgery
Open this publication in new window or tab >>In vitro and in vivo studies of tissue engineering in reconstructive plastic surgery
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Linköping: Unitryck, 2005. 75 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 905
National Category
Surgery
Research subject
Plastic Surgery
Identifiers
urn:nbn:se:uu:diva-286421 (URN)91-85299-06-5 (ISBN)
Public defence
2005-09-02, Linköping, 14:43 (English)
Opponent
Supervisors
Available from: 2016-04-22 Created: 2016-04-20 Last updated: 2016-04-22Bibliographically approved

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