uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Atrial function after left atrial epicardial cryoablation for atrial fibrillation in patients undergoing mitral valve surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi elektrokardiologi)
Show others and affiliations
2012 (English)In: Journal of interventional cardiac electrophysiology (Print), ISSN 1383-875X, E-ISSN 1572-8595, Vol. 33, no 1, 85-91 p.Article in journal (Refereed) Published
Abstract [en]


To explore the effects on atrial and ventricular function of restoring sinus rhythm (SR) after epicardial cryoablation and closure of the left atrial appendage (LAA) in patients with mitral valve disease and atrial fibrillation (AF) undergoing surgery.


Sixty-five patients with permanent AF were randomized to mitral valve surgery combined with left atrial epicardial cryoablation and LAA closure (ABL group, n = 30) or to mitral valve surgery alone (control group, n = 35). Two-dimensional and Doppler echocardiography were performed before and 6 months after surgery.


At 6 months, 73% of the patients in the ABL group and 46% of the controls were in SR. Patients in SR at 6 months had a reduction in their left ventricular diastolic diameter while the left ventricular ejection fraction was unchanged. In patients remaining in AF, the left ventricular ejection fraction was lower than at baseline. The left atrial diastolic volume was reduced after surgery, more in patients with SR than AF. In patients in SR, the peak velocity during the atrial contraction and the reservoir function were lower in the ABL group than in the control group.


In patients in SR, signs of atrial dysfunction were observed in the ABL but not the control group. Atrial dysfunction may have existed before surgery, but the difference between the groups implies that the cryoablation procedure and/or closure of the LAA might have contributed.

Place, publisher, year, edition, pages
2012. Vol. 33, no 1, 85-91 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-163009DOI: 10.1007/s10840-011-9605-xISI: 000300065700011PubMedID: 21935581OAI: oai:DiVA.org:uu-163009DiVA: diva2:462449
Available from: 2011-12-07 Created: 2011-12-07 Last updated: 2012-03-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Blomström, PerNilsson, LeifThelin, StefanBlomström-Lundqvist, Carina
By organisation
Department of Medical SciencesThoracic Surgery
In the same journal
Journal of interventional cardiac electrophysiology (Print)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 296 hits
ReferencesLink to record
Permanent link

Direct link