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Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Plattformen för preklinisk PET)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Endokrin diabetes och metabolism)
2011 (English)In: Journal of Transplantation, ISSN 2090-0007, E-ISSN 2090-0015, Vol. 2011, 352043- p.Article, review/survey (Refereed) Published
Abstract [en]

Islet transplantation is an attractive treatment for selected patients with brittle type 1 diabetes. In the clinical setting, intraportal transplantation predominates. However, due to extensive early islet cell death, the quantity of islets needed to restore glucose homeostasis requires in general a minimum of two donors. Moreover, the deterioration of islet function over time results in few insulin-independent patients after five-year followup. Specific obstacles to the success of islet transplantation include site-specific concerns for the liver such as the instant blood mediated inflammatory reaction, islet lipotoxicity, low oxygen tension, and poor revascularization, impediments that have led to the developing interest for alternative implantation sites over recent years. Within preclinical settings, several alternative sites have now been investigated and proven favorable in various aspects. Muscle is considered a very promising site and has physiologically properties and technical advantages that could make it optimal for islet transplantation.

Place, publisher, year, edition, pages
2011. Vol. 2011, 352043- p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-163313DOI: 10.1155/2011/352043OAI: oai:DiVA.org:uu-163313DiVA: diva2:463609
Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2017-12-08Bibliographically approved

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Espes, DanielEriksson, OlofLau, JoeyCarlsson, Per-Ola

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