Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D
2012 (English)In: Bone Marrow Transplantation, ISSN 0268-3369, E-ISSN 1476-5365, Vol. 47, no 5, 657-662 p.Article in journal (Refereed) Published
We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years after SCT. Fifteen patients had undergone auto-SCT and all patients had received TBI. The patients had significantly lower BMD in the total body, at the femoral neck, and in the total hip compared with age- and sex-matched controls. Six of 18 patients (33%) had low bone mass (z-score <−1) at one or more measurement sites, as opposed to two of the controls (11%, P=0.29). We found no significant influence of growth hormone levels or of untreated hypogonadism on BMD variables. Levels of 25-hydroxy (25(OH)) vitamin D were lower among the patients (35.2 vs 48.8 nmol/L, P=0.044) and were significantly correlated with total body BMD in the patient group (r=0.55, P=0.021). All six patients with low bone mass had hypovitaminosis D (37 nmol/L as opposed to 4 of the 11 (36%) patients without low bone mass (P=0.035). In conclusion, we found decreased BMD in SCT survivors, which may in part be caused by 25(OH) vitamin D deficiency.
Place, publisher, year, edition, pages
2012. Vol. 47, no 5, 657-662 p.
SCT, bone mineral density, dual-energy X-ray absorptiometry, growth hormone, 25(OH) vitamin D
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-163698DOI: 10.1038/bmt.2011.147ISI: 000303923500008PubMedID: 21765478OAI: oai:DiVA.org:uu-163698DiVA: diva2:464591