uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Tumor-associated epilepsy in patients with glioma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2011 (English)In: Tumors of the central nervous system. Vol. 2 / [ed] M. A. Hayat, Dordrecht: Springer Berlin/Heidelberg, 2011, 397-406 p.Chapter in book (Refereed)
Abstract [en]

Epileptic seizures are common symptoms in patients with glioma, occurring at disease presentation as well as during later disease. The frequency of tumor-related seizures is strongly related to the growth rate of the tumor. In low-grade gliomas, seizures as initial symptom leading to the brain tumor diagnosis occur in 70–90% of all patients. About 50% of these patients continue to have seizures before operation in spite of optimal antiepileptic drug treatment. In high-grade gliomas, seizures at disease presentation are less frequent and occur in only 30–50% of all patients but may be more difficult to control. Apart from the tumor growth rate, the specific location of the tumor in the brain and its proximity to the cortex affect seizure risk and seizure control in glioma. For many patients with tumor-related seizures, optimal seizure control is not achieved by antiepileptic drugs only but requires additional therapy such as surgical resection and/or radio- and chemotherapy. In this review, we discuss different aspects of the clinical presentation of the disease in patients with tumor-related seizures. We also discuss the possible therapeutic strategies for patients with medically refractory seizures, illustrating the importance of a qualified specialized team of neuro-oncologists, neurologists and neurosurgeons for the optimal management of this patient group.

Place, publisher, year, edition, pages
Dordrecht: Springer Berlin/Heidelberg, 2011. 397-406 p.
Keyword [en]
Epilepsy, glioma, antiepileptic drugs, epileptogenesis, differential diagnoses, ischemic infarction
National Category
Research subject
URN: urn:nbn:se:uu:diva-164128DOI: 10.1007/978-94-007-0618-7ISBN: 97-94-007-0617-0OAI: oai:DiVA.org:uu-164128DiVA: diva2:466574
Available from: 2011-12-16 Created: 2011-12-16 Last updated: 2013-03-15

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Smits, Anja
By organisation
Department of Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 177 hits
ReferencesLink to record
Permanent link

Direct link