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Regulation of keratin expression by retinoids
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
2011 (English)In: Dermato-endocrinology, ISSN 1938-1972, Vol. 3, no 3, 136-140 p.Article in journal (Refereed) Published
Abstract [en]

Vitamin A and its natural and synthetic metabolites (retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes. Keratins are intermediate filament proteins that have essential functions in maintaining the structural integrity of epidermis and its appendages. Their expressions are under strict control to produce keratins that are optimally adapted to their environment. In this article, retinoid regulation of keratin expression in cultured human epidermal keratinocytes and in human skin in vivo will be reviewed. The direct and indirect mechanisms involved will be discussed and novel therapeutic strategies will be proposed for utilizing retinoids in skin disorders due to keratin mutations (e.g., epidermolysis bullosa simplex and epidermolytic ichthyosis).

Place, publisher, year, edition, pages
2011. Vol. 3, no 3, 136-140 p.
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:uu:diva-164270DOI: 10.4161/derm.3.3.15026PubMedID: 22110773OAI: oai:DiVA.org:uu-164270DiVA: diva2:467098
Available from: 2011-12-19 Created: 2011-12-19 Last updated: 2012-02-02Bibliographically approved

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