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Influence of microstructure and chemical composition of sputter deposited TiO2 thin films on in vitro bioactivity
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Sandvik Tooling Sverige AB, Stockholm)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Sandvik Tooling Sverige AB, Stockholm.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.ORCID iD: 0000-0002-5496-9664
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2011 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 22, no 12, 2727-2734 p.Article in journal (Refereed) Published
Abstract [en]

Functionalisation of biomedical implants viasurface modifications for tailored tissue response is agrowing field of research. Crystalline TiO2 has been provento be a bone bioactive, non-resorbable material. In contactwith body fluids a hydroxyapaptite (HA) layer forms on itssurface facilitating the bone contact. Thus, the path ofimproving biomedical implants via deposition of crystallineTiO2 on the surface is interesting to follow. In thisstudy we have evaluated the influence of microstructureand chemical composition of sputter deposited titaniumoxide thin films on the in vitro bioactivity. We find thatboth substrate bias, topography and the flow ratio of thegases used during sputtering affect the HA layer formed onthe films after immersion in simulated body fluid at 37C.A random distribution of anatase and rutile crystals, formedat negative substrate bias and low Ar to O2 gas flow ratios,are shown to favor the growth of flat HA crystal structureswhereas higher flow ratios and positive substrate biasinduced growth of more spherical HA structures. Thesefindings should provide valuable information when optimizingthe bioactivity of titanium oxide coatings as well asfor tailoring process parameters for sputtered-based productionof bioactive titanium oxide implant surfaces.

Place, publisher, year, edition, pages
Springer, 2011. Vol. 22, no 12, 2727-2734 p.
Keyword [en]
TiO2, bioactivity, PVD, biomimetic deposition, Hydroxyapatite
National Category
Materials Engineering Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-164530DOI: 10.1007/s10856-011-4465-6ISI: 000297621700014PubMedID: 22052535OAI: oai:DiVA.org:uu-164530DiVA: diva2:468469
Projects
Surface structure optimized bioactive surgical implant coatings with optional drug delivery function
Available from: 2011-12-21 Created: 2011-12-21 Last updated: 2017-12-08Bibliographically approved

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Lilja, MirjamStrømme, MariaEngqvist, Håkan

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