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Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2011 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 197, 145-152 p.Article in journal (Refereed) Published
Abstract [en]

A 13-amino acid peptide named neuronostatin (NST) encoded in the somatostatin pro-hormone has been recently reported. It is produced throughout the body, particularly in brain areas that have significant actions over the metabolic and autonomic regulation. The present study was performed in order to elucidate the functional role of NST on memory, anxiety-like behavior and food intake and the hippocampal participation in these effects. When the peptide was intra-hippocampally administered at 3.0 nmol/mu l, it impaired memory retention in both, object recognition and step-down test. Also, this dose blocked the hippocampal long-term potentiation (LTP) generation. When NST was intra-hippocampally administered at 0.3 nmol/mu l and 3.0 nmol/mu l, anxiolytic effects were observed. Also, the administration in the third ventricle at the higher dose (3.0 nmol/mu l) induced similar effects, and both doses reduced food intake. The main result of the present study is the relevance of the hippocampal formation in the behavioral effects induced by NST, and these effects could be associated to a reduced hippocampal synaptic plasticity.

Place, publisher, year, edition, pages
2011. Vol. 197, 145-152 p.
Keyword [en]
neuronostatin, memory performance, hippocampal excitability, anxiety-like behavior, food intake
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-164548DOI: 10.1016/j.neuroscience.2011.09.040ISI: 000297140700015OAI: oai:DiVA.org:uu-164548DiVA: diva2:468663
Available from: 2011-12-21 Created: 2011-12-21 Last updated: 2017-12-08Bibliographically approved

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Schioth, Helgi B.

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