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Comparative evaluation of the reticulocyte hemoglobin content assay when screening for iron deficiency in elderly anemic patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Hematologi)
2011 (English)In: Anemia, ISSN 2090-1275, Vol. 2011, 925907- p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). Sensitivity and specificity for CHr, soluble transferrin receptor (sTfR), soluble transferrin receptor/log ferritin (TfR-F index), ferritin, MCH, and transferrin saturation were determined. The best cut-off point for CHr was 30.5 pg corresponding to a sensitivity and specificity of 93% and 69% for IDA, respectively. For MCH, a sensitivity of 93% and a specificity of 86%, respectively, correspond to an optimal cut-off of 28.5 pg. Analysis of CHr was not superior to MCH with respect to sensitivity and specificity when screening for IDA in elderly anemic patients.

Place, publisher, year, edition, pages
2011. Vol. 2011, 925907- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-164767DOI: 10.1155/2011/925907PubMedID: 21808729Local ID: 925907OAI: oai:DiVA.org:uu-164767DiVA: diva2:469769
Available from: 2011-12-27 Created: 2011-12-27 Last updated: 2012-01-20Bibliographically approved

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