Decreased blood loss after cardiopulmonary bypass using heparin-coated circuit and 50% reduction of heparin dose
1992 (English)In: Scandinavian journal of thoracic and cardiovascular surgery, ISSN 0036-5580, Vol. 26, no 3, 177-185 p.Article in journal (Refereed) Published
In a randomized, double-blind study of patients undergoing elective coronary artery grafting, the effect of heparin-coated circuit combined with 50% reduction of systemic heparin bolus was investigated. Ten patients comprised group HC (heparin-coated) and ten group C (controls). The mean total doses of heparin were 172 IU/kg in group HC and 416 IU/kg in group C and the respective protamine doses were 0.96 and 3.96 mg/kg (both p < 0.001). Activated clotting times during cardiopulmonary bypass were significantly shorter in group HC, and both intra- and postoperative bleeding was significantly less than in group C (7.7 vs. 11.7 ml/kg, p = 0.036, and 6.9 vs. 9.7 ml/kg, p = 0.004). Hemoglobin loss via the drains was 22.5 g in group HC and 43.7 g in group C (p < 0.005). Hemolysis at the end of bypass was significantly greater in group C. Apart from one perioperative myocardial infarction in group HC the postoperative course was uneventful. Use of a heparin-coated circuit is concluded to permit complication-free reduction of heparin and protamine doses and to decrease both intra- and postoperative bleeding, which may favorably influence the outcome of coronary artery grafting.
Place, publisher, year, edition, pages
1992. Vol. 26, no 3, 177-185 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-165182PubMedID: 1287831OAI: oai:DiVA.org:uu-165182DiVA: diva2:472275