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In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials
Nanologica AB, Stockholm, och Dept of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University.
Nanologica AB, Stockholm.
Diseases of the Developing World, GlaxoSmithKline, Madrid, Spanien.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
2012 (English)In: ChemMedChem, ISSN 1860-7179, Vol. 7, no 1, 43-8 p.Article in journal (Refereed) Published
Abstract [en]

Matters of the HAART! The current treatment for human immunodeficiency virus (HIV), HAART, makes use of a combination of antiretroviral drugs, which are poorly soluble in aqueous media. Enhancing the solubility of such drugs through the use of mesoporous materials could lead to improved treatment efficiency and might provide a solution to the drug-drug interaction problems associated with these types of therapeutic regimes.

Place, publisher, year, edition, pages
2012. Vol. 7, no 1, 43-8 p.
Keyword [en]
drug delivery, human immunodeficiency virus (HIV), mesoporous silica, proton-pump inhibitors, solubility
National Category
Pharmaceutical Biotechnology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-165287DOI: 10.1002/cmdc.201100500ISI: 000298549100004PubMedID: 22144293OAI: oai:DiVA.org:uu-165287DiVA: diva2:472812
Swedish Research Council
Available from: 2012-01-04 Created: 2012-01-04 Last updated: 2012-09-21Bibliographically approved

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Garcia-Bennett, Alfonso E
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