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Fear conditioning and brain activity: a positron emission tomography study in humans.
Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
Department of Education.
Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Psychology.
2000 (English)In: Behav Neurosci, ISSN 0735-7044, Vol. 114, no 4, 671-80 p.Article in journal (Other scientific) Published
Abstract [en]

Regional cerebral blood flow (rCBF) was measured with H2 (15)O positron emission tomography in 8 healthy women before and after fear conditioning (i.e., paired shocks) and unpaired shocks to videotape cues. Conditioning was supported by enhanced peripheral nervous system recordings and subjective ratings. Fear conditioning increased rCBF in the central gray of the midbrain; bilaterally in the hypothalamus, the thalamus, and the left striatum; and in the right and left anterior cingulate and right prefrontal cortices. Regional CBF was attenuated bilaterally in the right and left prefrontal, temporal (including the amygdala), parietal, and occipital cortices, and in the left orbitofrontal cortex. When compared with unpaired shock presentations, fear conditioning resulted in elevated rCBF in the left cerebellum. Hence, in the present paradigm, only neural activity in the left cerebellum solely reflected processes associated with true Pavlovian conditioning.

Place, publisher, year, edition, pages
2000. Vol. 114, no 4, 671-80 p.
Keyword [en]
Adult, Arousal/physiology, Brain/blood supply/*radionuclide imaging, Brain Mapping, Cerebellum/physiology/radionuclide imaging, Conditioning; Classical/*physiology, Dominance; Cerebral/physiology, Fear/*physiology, Female, Humans, Regional Blood Flow/physiology, Research Support; Non-U.S. Gov't, Tomography; Emission-Computed
Identifiers
URN: urn:nbn:se:uu:diva-19510PubMedID: 10959525OAI: oai:DiVA.org:uu-19510DiVA: diva2:47282
Available from: 2006-11-29 Created: 2006-11-29 Last updated: 2011-01-14

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