Long-term functional outcome after restorative proctocolectomy in patients with ulcerative colitis
2012 (English)In: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318, Vol. 14, no 8, 977-984 p.Article in journal (Refereed) Published
The aim of this study was to evaluate long-term functional outcome of ileal pouch-anal anastomosis for ulcerative colitis and to compare symptoms over time.
188 patients were operated with an ileal pouch-anal anastomosis. Short-term functional outcome has previously been evaluated with a symptom questionnaire. The same questionnaire was sent to the 162 patients who were alive and had an intact pouch. A symptom index was studied over time and in relation to early complications and pouchitis.
The response rate of the questionnaire was 139/162 at a median of 12.5 (9.5-21) years postoperatively. Overall, the symptom index remained unchanged over time but both the frequency of night-time defecation and episodes of night time incontinence increased. Patients' global assessment was unchanged with approximately 80 per cent stating an excellent or a good result. Frequency of pouchitis doubled in ten years. Symptom index for patients with episodic pouchitis (median 40 (8-89), p=0.018) and recurrent/chronic pouchitis (71 (8-136), p<0.001) was higher than in patients without pouchitis (29 (0-105). Early complications did not affect the symptom index.
The overall functional outcome of ileal pouch-anal surgery for ulcerative colitis is stable over time. Patients' satisfaction with outcome remains high. Pouchitis is a determinant of functional outcome.
Place, publisher, year, edition, pages
2012. Vol. 14, no 8, 977-984 p.
Ulcerative colitis, restorative proctocolectomy, ileal pouch–anal anastomosis, functional outcome
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-165332DOI: 10.1111/j.1463-1318.2011.02873.xISI: 000306901200022PubMedID: 22053822OAI: oai:DiVA.org:uu-165332DiVA: diva2:473041