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Microgels and microcapsules in peptide and protein drug delivery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0002-0895-1180
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2011 (English)In: Advanced Drug Delivery Reviews, ISSN 0169-409X, E-ISSN 1872-8294, Vol. 63, no 13, 1172-1185 p.Article, review/survey (Refereed) Published
Abstract [en]

The present review focuses on the interaction of microgels and microcapsules with biological macromolecules, particularly peptides and proteins, as well as drug delivery applications of such systems. Results from recent studies on factors affecting peptide/protein binding to, and release from, microgels and related systems are discussed, including effects of network properties, as well as protein aggregation, peptide length, hydrophobicity and charge (distributions), secondary structure, and cyclization. Effects of ambient conditions (pH, ionic strength, temperature, etc.) are also discussed, all with focus on factors of importance for the performance of microgel and microcapsule delivery systems for biomacromolecular drugs.

Place, publisher, year, edition, pages
2011. Vol. 63, no 13, 1172-1185 p.
Keyword [en]
Biomacromolecules, DNA, Drug delivery, Microgel, Microcapsule, Peptide, Protein, siRNA
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-165295DOI: 10.1016/j.addr.2011.08.005ISI: 000296996800008OAI: oai:DiVA.org:uu-165295DiVA: diva2:474065
Available from: 2012-01-09 Created: 2012-01-04 Last updated: 2017-12-08Bibliographically approved

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Månsson, RonjaHansson, PerMalmsten, Martin

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