Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
2011 (English)In: Journal of Parkinson's Disease, ISSN 1877-7171, E-ISSN 1877-718X, Vol. 1, no 4, 347-357 p.Article in journal (Refereed) Published
The transcription factor FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson´s disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classiﬁed as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/ FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/ FosB-positive cells did not differ signiﬁcantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/ FosB immunoreactivity was found in the in the pallidum externum and internum, and no signiﬁcant group differences were detected in these nuclei. The putaminal elevation of FosB/ FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present ﬁndings support the hypothesis of an involvement of FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.
Place, publisher, year, edition, pages
IOS Press, 2011. Vol. 1, no 4, 347-357 p.
Motor complications, immediate-early genes, striatonigral, striatopallidal, medium-spiny neurons, neurodegenera- tion, dopaminergic therapies
Research subject Neurology
IdentifiersURN: urn:nbn:se:uu:diva-165526DOI: 10.3233/JPD-2011-11068ISI: 000308484300005PubMedID: 23933656OAI: oai:DiVA.org:uu-165526DiVA: diva2:474115