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Putaminal Upregulation of FosB/ΔFosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
Lund University. (Basal Ganglia Pathophysiology Unit)
Lund University. (Basal Ganglia Pathophysiology Unit)
Lund University. (Basal Ganglia Pathophysiology Unit)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neurotoxicity/Drug Safety and Toxicity)
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2011 (English)In: Journal of Parkinson's Disease, ISSN 1877-7171, E-ISSN 1877-718X, Vol. 1, no 4, 347-357 p.Article in journal (Refereed) Published
Abstract [en]

The transcription factor FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson´s disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/ FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/ FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/ FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/ FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.

Place, publisher, year, edition, pages
IOS Press, 2011. Vol. 1, no 4, 347-357 p.
Keyword [en]
Motor complications, immediate-early genes, striatonigral, striatopallidal, medium-spiny neurons, neurodegenera- tion, dopaminergic therapies
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Research subject
URN: urn:nbn:se:uu:diva-165526DOI: 10.3233/JPD-2011-11068ISI: 000308484300005PubMedID: 23933656OAI: oai:DiVA.org:uu-165526DiVA: diva2:474115
Available from: 2012-01-09 Created: 2012-01-09 Last updated: 2014-08-15Bibliographically approved

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