A mammalian like interleukin-1 receptor-associated kinase 4 (IRAK-4), a TIR signaling mediator in intestinal innate immunity of black tiger shrimp (Penaeus monodon)
2012 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 417, no 1, 623-629 p.Article in journal (Refereed) Published
Interleukin-1 receptor associated kinase-4 (IRAK-4) has been identified as a central signal transduction mediator of the Toll-like receptor (TLR) and Toll/interleukin-1 receptor (TIR) pathways in vertebrate innate immunity. An IRAK-4 homologue was cloned from the black tiger shrimp (Penaeus monodon) (PmIRAK-4) and it shares domains and structures with other IRAK-4s. It was found to be mainly expressed in the hemocytes and midgut but also to a lower extent in several other tissues in shrimp. The PmIRAK-4 responded to bacterial infection in the intestine by an enhancement of its expression level. These results indicate that PmIRAK-4 may play a role at least in the intestinal innate immunity of P. monodon.
Place, publisher, year, edition, pages
2012. Vol. 417, no 1, 623-629 p.
Research subject Biology with specialization in Comparative Physiology
IdentifiersURN: urn:nbn:se:uu:diva-165584DOI: 10.1016/j.bbrc.2011.12.019ISI: 000299491600106PubMedID: 22182410OAI: oai:DiVA.org:uu-165584DiVA: diva2:474376