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Role of TGF-β signaling in EMT, cancer progression and metastasis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2011 (English)In: Drug Discovery Today : Disease Models, ISSN 1740-6757, E-ISSN 1740-6757, Vol. 8, no 2-3, 121-126 p.Article in journal (Refereed) Published
Abstract [en]

Transforming growth factor b (TGFb) signaling isimplicated in cancer progression since its discovery.Although TGFb plays tumor suppressor roles, thesame pathway also provides pro-tumorigenic fates.The pro-tumorigenic action of TGFb involves processeslike epithelial–mesenchymal transition (EMT),tumor microenvironment remodeling, and eventuallymetastatic dissemination to new sites of tumor growth.Here, we give an updated overview of TGFb roles intumor progression and emphasize current evaluationsof TGFb blockade in preventing EMT and metastasis.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 8, no 2-3, 121-126 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-166127DOI: 10.1016/j.ddmod.2011.07.009OAI: oai:DiVA.org:uu-166127DiVA: diva2:475339
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08Bibliographically approved

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Ludwig Institute for Cancer ResearchDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
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Drug Discovery Today : Disease Models
Medical and Health Sciences

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