uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Show others and affiliations
2012 (English)In: Addiction Biology, ISSN 1355-6215, Vol. 17, no 1, 132-140 p.Article in journal (Refereed) Published
Abstract [en]

The effects of repeated, intermittent administration of a moderate dose of ethanol (3.4 g/kg/day × 6 days, intragastrically via gavages) on cognitive function were examined in male Wistar rats. No significant differences in weight gain between the ethanol- and water-treated rats were found. Analysis of physical dependence revealed no signs of spontaneous withdrawal, whereas withdrawal signs exacerbated by Ro15-4513, an inverse benzodiazepine agonist, were apparent 5 hours but not 24 hours after the cessation of ethanol treatment. Spatial learning and memory, as assessed in the Barnes maze, were impaired 3-6 days following the treatment but recovered by the 11th-14th days. Reversal learning, however, was impaired throughout the 2-week observation period. Thus, bouts of moderate-dose ethanol administration transiently impair spatial learning and memory, and promote cognitive inflexibility. The employed ethanol exposure paradigm may provide a model of human cognitive deficits associated with alcohol binge drinking.

Place, publisher, year, edition, pages
2012. Vol. 17, no 1, 132-140 p.
Keyword [en]
Animal model, behavioral flexibility, binge drinking, cognitive impairment, ethanol, rat, spatial learning
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-166180DOI: 10.1111/j.1369-1600.2010.00224.xISI: 000298303000011PubMedID: 22026443OAI: oai:DiVA.org:uu-166180DiVA: diva2:475528
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2012-01-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bakalkin, Georgy
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Addiction Biology
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 207 hits
ReferencesLink to record
Permanent link

Direct link