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Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2012 (English)In: Addiction Biology, ISSN 1355-6215, E-ISSN 1369-1600, Vol. 17, no 1, 132-140 p.Article in journal (Refereed) Published
Abstract [en]

The effects of repeated, intermittent administration of a moderate dose of ethanol (3.4 g/kg/day × 6 days, intragastrically via gavages) on cognitive function were examined in male Wistar rats. No significant differences in weight gain between the ethanol- and water-treated rats were found. Analysis of physical dependence revealed no signs of spontaneous withdrawal, whereas withdrawal signs exacerbated by Ro15-4513, an inverse benzodiazepine agonist, were apparent 5 hours but not 24 hours after the cessation of ethanol treatment. Spatial learning and memory, as assessed in the Barnes maze, were impaired 3-6 days following the treatment but recovered by the 11th-14th days. Reversal learning, however, was impaired throughout the 2-week observation period. Thus, bouts of moderate-dose ethanol administration transiently impair spatial learning and memory, and promote cognitive inflexibility. The employed ethanol exposure paradigm may provide a model of human cognitive deficits associated with alcohol binge drinking.

Place, publisher, year, edition, pages
2012. Vol. 17, no 1, 132-140 p.
Keyword [en]
Animal model, behavioral flexibility, binge drinking, cognitive impairment, ethanol, rat, spatial learning
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-166180DOI: 10.1111/j.1369-1600.2010.00224.xISI: 000298303000011PubMedID: 22026443OAI: oai:DiVA.org:uu-166180DiVA: diva2:475528
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08Bibliographically approved

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Bakalkin, Georgy

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