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Reproducibility of munix in patients with amyotrophic lateral sclerosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2011 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 44, no 6, 919-922 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: In this study we investigated the reproducibility of motor unit number index (MUNIX) in patients with amyotrophic lateral sclerosis (ALS). Methods: MUNIX was recorded in patients with ALS. Studies were performed in 18 thenar and 18 hypothenar muscles by two operators. The reproducibility was assessed using mean MUNIX values, linear regression, correlation coefficient, and coefficient of variation (COV) in individual studies. Results: The mean values showed no significant difference. The linear regression showed a strong correlation. Most patients had low COV. A high COV was seen when MUNIX was very low. The COV was higher in thenar than in hypothenar muscles. Conclusions: MUNIX has very good reproducibility in ALS patients. COV may exaggerate interoperator variation when MUNIX is very low. The higher variability in the thenar muscle is also due to variability in compound muscle action potential amplitude. Although both muscles show good reproducibility, the hypothenar is better suited for serial studies in individual patients.

Place, publisher, year, edition, pages
2011. Vol. 44, no 6, 919-922 p.
Keyword [en]
ALS, compound muscle action potential, hypothenar, MUNIX, reproducibility, thenar
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-166727DOI: 10.1002/mus.22204ISI: 000297938800013OAI: oai:DiVA.org:uu-166727DiVA: diva2:477625
Available from: 2012-01-13 Created: 2012-01-13 Last updated: 2012-01-13Bibliographically approved

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Stålberg, Erik V.
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