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Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnendokrinologisk forskning/Tuvemo)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnendokrinologisk forskning/Tuvemo)
2006 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 49, no 11, 2697-2703 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis: Enterovirus infections have long been suspected to be environmental factors that may cause type 1 diabetes, but the pathways leading from infection to beta cell destruction are still unknown. We therefore examined whether enterovirus infection of human islets leads to upregulation of interferon-gamma-inducible protein (IP-10, now known as chemokine [C-X-C motif] ligand 10 [CXCL10]), a chemokine important for the induction of insulitis. Methods: Isolated human islets were infected with three different strains of Coxsackie B4 virus. IP-10 expression and secretion from the infected human islets were then measured using RT-PCR and ELISA at several time points. Results: IP-10 was clearly upregulated in and secreted from human islets during enterovirus infection. This was demonstrated with three different strains of Coxsackie B4 virus, two of which are lytic to islets and one which is non-lytic and can establish a persistent infection in human islets. Conclusions/interpretation: We propose that enterovirus-induced upregulation of IP-10 during infection of the islets in vivo is the first step towards destructive insulitis. Our findings support the idea that enterovirus infection triggers immune-mediated beta cell destruction, and for the first time suggest a possible mechanism behind enterovirus-induced diabetes.

Place, publisher, year, edition, pages
2006. Vol. 49, no 11, 2697-2703 p.
Keyword [en]
Chemokines, Enterovirus, Human islets, IP-10, Picornavirus, Type 1 diabetes
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-20071DOI: 10.1007/s00125-006-0429-7ISI: 000241578600025PubMedID: 16969644OAI: oai:DiVA.org:uu-20071DiVA: diva2:47843
Available from: 2007-03-06 Created: 2007-03-06 Last updated: 2017-12-08Bibliographically approved

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Berg, Anna-KarinFrisk, Gun

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