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Maternal and paternal psychopathology increases risk of offspring ADHD equally
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
2011 (English)In: Epidemiology and Psychiatric Sciences, ISSN 2045-7960, Vol. 20, no 4, 367-372 p.Article in journal (Refereed) Published
Abstract [en]

Background. Parental psychopathology may increase the risk of attention-deficit hyperactivity disorder (ADHD) in the offspring. The aim of this study was to analyze if/how gender influences the association between parental psychiatric/addictive disorders and ADHD medication in the offspring.

Methods. Register study in national birth cohorts of 1.1 million 6-19-year-olds. In this population, 7960 individuals with ADHD medication were identified in the Swedish Prescribed Drug Register during 2006. Data on parental psychiatric/addictive disorders and suicide death were obtained through linkages to national registers. Logistic regression was used for analyses with multiple adjustments for socio-economic, regional and demographic confounders.

Results. Parental diagnosis related to illicit drugs was associated with the highest odds ratios (ORs) of ADHD medication (OR: similar to 3.5-4), followed by suicide attempt/death (OR: similar to 3-3.5), alcohol (OR: similar to 2.5-3), affective disorder (OR: similar to 2.5) and psychosis (OR: similar to 2-2.5). The ORs were of similar magnitudes for maternal and paternal psychopathology and did not vary by the gender of the offspring. Adjusting for social characteristics decreased the ORs substantially and in the same way regarding fathers' and mothers' possible influence on the risk of ADHD in children.

Conclusions. Neither parental nor offspring gender seems to influence the link between parental addictive/psychiatric disorder and offspring ADHD.

Place, publisher, year, edition, pages
2011. Vol. 20, no 4, 367-372 p.
Keyword [en]
ADHD, central stimulants, parental psychopathology, register study
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-166860DOI: 10.1017/S2045796011000564ISI: 000298053400012OAI: oai:DiVA.org:uu-166860DiVA: diva2:479019
Available from: 2012-01-17 Created: 2012-01-16 Last updated: 2012-01-17Bibliographically approved

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