In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency
2007 (English)In: Journal of chemical information and modeling, ISSN 1549-9596, Vol. 47, no 1, 239-248 p.Article in journal (Refereed) Published
A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in.
Place, publisher, year, edition, pages
2007. Vol. 47, no 1, 239-248 p.
computers in chemistry, computer program
Medical and Health Sciences Signal Processing
Research subject Electrical Engineering with specialization in Signal Processing
IdentifiersURN: urn:nbn:se:uu:diva-20891DOI: 10.1021/ci060073nISI: 000243577400029PubMedID: 17238270OAI: oai:DiVA.org:uu-20891DiVA: diva2:48664