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Agreement between physicians' and patients' ratings on the Montgomery-Asberg Depression Rating Scale
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
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2011 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 135, no 1-3, 148-153 p.Article in journal (Refereed) Published
Abstract [en]

Background: Self-rating scales developed for monitoring depression severity are potentially informative and cost effective tools. There is an increasing tendency to use the Montgomery-Asberg Depression Rating Scale (MADRS) and the self-rating version (MADRS-S) interchangeably.

Methods: 400 patients with major depressive disorder were included. Concordance between patient and physician ratings was measured by means of repeated MADRS and MADRS-S ratings during a six-month drug trial and one-year follow-up.

Results: Overall scores from patients and physicians show the same trends and both are sensitive to improvements. Our results, however, show only moderate to good agreement between patient and physician ratings. Intraclass coefficients ranged from 0.47 to 0.75 with highest agreement at week 8.

Limitations: Generalizability is restricted to outpatients in general practice with moderate to severe depression. MADRS-S and MADRS scale definitions are similar but not identical concerning language and are scaled differently, 0-6 vs. 0-3, respectively, which may have influenced the results. The exclusion criteria restricted the range of values for the item Suicidal thoughts/Zest for life, which may have reduced the correlations.

Conclusions: MADRS-S is a suitable tool for following patients' symptoms on a regular basis over time and may also be used to compensate for bias in physicians' ratings in drug trials.

Place, publisher, year, edition, pages
2011. Vol. 135, no 1-3, 148-153 p.
Keyword [en]
Montgomery-Asberg Depression Rating Scale, Self-rating scales, Depression
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-167930DOI: 10.1016/j.jad.2011.07.005ISI: 000297908200021OAI: oai:DiVA.org:uu-167930DiVA: diva2:489062
Available from: 2012-02-02 Created: 2012-02-02 Last updated: 2017-12-08Bibliographically approved

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Cunningham, Janet L.Wernroth, Lisavon Knorring, LarsBerglund, LarsEkselius, Lisa

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