uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Retrospenial cortical deactivation during painful stimulation of fibromyalgic patients.
Show others and affiliations
2006 (English)In: Int J Neurosci, ISSN 0020-7454, Vol. 116, no 1, 1-8 p.Article in journal (Refereed) Published
Abstract [en]

To study fibromyalgic pain this article contrasts positron emission tomographic measures of regional cerebral blood flow (rCBF) during externally induced acute pain and rest in eight fibromyalgia syndrome patients. An expected pattern of frontal and parietal cortical activation during acute pain as compared to rest was observed. However, reduced rCBF was additionally found in the retrosplenial cortex during acute pain as compared to rest. This may reflect that externally induced pain inhibits fibromyalgic pain and syndrome-related evaluative processes located in the retrosplenial cortex, and that fibromyalgic pain results from exaggerated attention to sub-noxious pain signaling, that is, secondary hyperalgesia.

Place, publisher, year, edition, pages
2006. Vol. 116, no 1, 1-8 p.
Keyword [en]
Adult, Arousal, Brain Mapping, Cerebrovascular Circulation, Female, Fibromyalgia/complications/*physiopathology, Frontal Lobe/blood supply/*physiopathology/radionuclide imaging, Humans, Hyperalgesia/complications/*physiopathology, Laterality, Middle Aged, Neural Pathways/physiopathology, Pain/*physiopathology, Pain Threshold, Parietal Lobe/blood supply/*physiopathology/radionuclide imaging, Positron-Emission Tomography, Research Support; Non-U.S. Gov't
URN: urn:nbn:se:uu:diva-21272PubMedID: 16318995OAI: oai:DiVA.org:uu-21272DiVA: diva2:49045
Available from: 2006-12-18 Created: 2006-12-18 Last updated: 2011-01-11

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Fredrikson, Mats
By organisation
Department of Psychology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
ReferencesLink to record
Permanent link

Direct link