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Gastrin-releasing-peptide in neuroendorine tumours
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi, Kjell Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Endokrin tumörbiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi, Kjell Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
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2006 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 45, no 1, 23-27 p.Article in journal (Refereed) Published
Abstract [en]

In a substantial proportion of cases with endocrine malignant disease the primary lesion cannot be localised and the pathologist hesitates upon the origin of the tumour. Well differentiated neuroendocrine carcinomas of the small bowel can usually be identified by the strong serotonin immunoreactivity, but foregut carcinoids may also stain positive for serotonin and the differential diagnosis between the various foregut tumours may be difficult. We examined if immunostaining for gastrin-releasing-peptide (GRP) may aid in establishing the origin of an unknown neuroendocrine tumour. Tumour tissue from 79 patients (27 lung carcinoids, 4 thymic carcinoids, 4 gastric neuroendocrine tumours, 17 pancreatic well differentiated neuroendocrine carcinomas, 1 duodenal well differentiated neuroendocrine tumour and 26 well differentiated neuroendocrine carcinomas of the small bowel) were immunostained with antibodies against GRP and serotonin. Positive staining for GRP was found in 12/27 lung carcinoids. All other tumour types were consistently GRP-negative (p?<?0.0001). We conclude that immunostaining for GRP may aid in defining the origin of the tumour, and that GRP-immunoreactivity increases the suspicion of a lung carcinoid.

Place, publisher, year, edition, pages
2006. Vol. 45, no 1, 23-27 p.
Keyword [en]
Diagnosis; Differential, Female, Gastrins/*biosynthesis, Gastrointestinal Neoplasms/*secondary, Humans, Immunohistochemistry, Lung Neoplasms/*secondary, Middle Aged, Neoplasms; Unknown Primary/*diagnosis/metabolism, Neuroendocrine Tumors/metabolism/*pathology, Peptides/*metabolism, Prospective Studies, Thymus Neoplasms/*secondary
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-21379DOI: 10.1080/02841860500367434PubMedID: 16464792OAI: oai:DiVA.org:uu-21379DiVA: diva2:49152
Available from: 2007-02-24 Created: 2007-02-24 Last updated: 2017-12-08Bibliographically approved

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Granberg, DanSkogseid, BrittÖrlefors, Håkan

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