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[111In-DTPA-D-Phe1]octreotide scintigraphy in patients with carcinoid tumours: the predictive value for somatostatin analogue treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (onkologisk endokrinologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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1994 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 131, no 6, 577-581 p.Article in journal (Refereed) Published
Abstract [en]

This study was performed to evaluate whether the presence or absence of somatostatin receptors in malignant carcinoid tumours detected by [111In-DTPA-D-Phe1]octreotide scintigraphy can be used to predict response to somatostatin analogue treatment. Thirty patients were investigated, 28 with midgut carcinoid tumours and two with foregut carcinoid tumours. Twenty-seven patients showed pathological uptake in tumour lesions at scintigraphy; of these, 22 responded to somatostatin analogue treatment using octreotide, somatuline or octastatin, while five patients failed to respond. None of the three patients displaying negative scintigraphic investigations responded to treatment with somatostatin analogues. These results show a good correlation between the somatostatin receptor status and the patients' ability to respond to somatostatin analogue treatment (p = 0.014). We conclude that somatostatin receptor scintigraphy using [111In-DTPA-D-Phe1]octreotide can be used to select patients with malignant carcinoid tumours suitable for somatostatin analogue treatment and exclude those that will not benefit from such medication.

Place, publisher, year, edition, pages
1994. Vol. 131, no 6, 577-581 p.
Keyword [en]
Aged, Carcinoid Tumor/*diagnosis/drug therapy, Female, Forecasting, Humans, Indium Radioisotopes/diagnostic use, Intestinal Neoplasms/*diagnosis/drug therapy, Male, Middle Aged, Octreotide/*analogs & derivatives/diagnostic use/therapeutic use, Pentetic Acid/*analogs & derivatives/diagnostic use, Peptides; Cyclic, Prospective Studies, Radionuclide Imaging, Retrospective Studies, Somatostatin/analogs & derivatives/therapeutic use, Tomography; X-Ray Computed, Treatment Outcome
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-21440DOI: 10.1530/eje.0.1310577PubMedID: 7804439OAI: oai:DiVA.org:uu-21440DiVA: diva2:49213
Available from: 2006-12-28 Created: 2006-12-28 Last updated: 2011-10-27Bibliographically approved

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Tiensuu Janson, Eva
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