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Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. (biologiska membran)
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2006 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 12, no 43, 7012-7018 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To study the effect of oral steroids upon clinical response and rectal mucosa secretion of eosinophil cationic protein (ECP), myeloperoxiclase (MPO), basic fibroblast growth factor (bFGF), vascular enclothelial growth factor (VEGF) and albumin in patients with collagenous colitis (CC).

METHODS: A segmental perfusion technique was used to collect perfusates from rectum of CC patients once before and twice (one and four weeks) after the start of steroid treatment. Clinical data was monitored and ECP, MPO, bFGF, VEGF and albumin concentrations were analyzed by immunochernical methods in perfusates and in serum.

RESULTS: Steroids reduced the number of bowel movements by more than five times within one week and all patients reported improved subjective wellbeing at wk 1 and 4. At the same time, the median concentrations of ECP, bFGF, VEGF and albumin in rectal perfusates decreased significantly. MPO values were above the detection limit in only 3 patients before treatment and in none during treatment. VEGF, bFGF, ECP and albumin concentrations correlated with each other with the exception of ECP and albumin. A decrease of serum ECP and VEGF concentrations was also seen even if the overtime reduction was not significant.

CONCLUSION: Oral steroid treatment in CC patients induced a simultaneous reduction of bowel movements and rectal release of ECP, bFGF, VEGF and albumin, suggesting that these polypeptides and increased mucosal permeability are important components of the pathophysiology in collagenous colitis.

Place, publisher, year, edition, pages
2006. Vol. 12, no 43, 7012-7018 p.
Keyword [en]
collagenous colitis, inflammatory mediator, steroid treatment, eosinophil cationic protein, basic fibroblast growth factor, vascular endothelial growth factor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-21808ISI: 000242299300016PubMedID: 17109497OAI: oai:DiVA.org:uu-21808DiVA: diva2:49581
Available from: 2007-01-04 Created: 2007-01-04 Last updated: 2017-12-07Bibliographically approved

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Carlson, MarieLarsson, AndersLööf, LarsThörn, Magnus

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Department of Medical SciencesDepartment of Surgical SciencesClinical ChemistryCentre for Clinical Research, County of Västmanland
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