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Co-localization of COX-2, CYP4F8 and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Dermatologi o venereologi. (Dermatologi o venereologi)
2006 (English)In: Prostaglandins & other lipid mediators, ISSN 1098-8823, Vol. 79, no 1-2, 114-125 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

Cyclooxygenase-2 (COX-2), cytochrome P450 4F8 (CYP4F8), and microsomal PGE synthase-1 (mPGES-1) form PGE and 19-hydroxy-PGE in human seminal vesicles. We have examined COX-2, CYP4F8, and mPGES-1 in normal skin and in psoriasis. All three enzymes were detected in epidermis by immunofluorescence and co-localized in the suprabasal cell layers. In lesional psoriasis the enzymes were also co-localized in the basal cell layers. Real-time RT-PCR analysis suggested that CYP4F8 mRNA was induced 15-fold in lesional compared to non-lesional epidermis. mRNA of all enzymes were present in cultured HEK and HaCaT cells, but the prominent induction of CYP4F8 mRNA in psoriasis could not be mimicked by treatment of these keratinocytes with a mixture of inflammatory cytokines or with phorbol 12-myristate-13-acetate. The function of CYP4F8 in epidermis might be related to lipid oxidation and keratinocyte proliferation.

Place, publisher, year, edition, pages
2006. Vol. 79, no 1-2, 114-125 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-22132DOI: 10.1016/j.prostaglandins.2005.12.003PubMedID: 16516815OAI: oai:DiVA.org:uu-22132DiVA: diva2:49905
Available from: 2008-06-27 Created: 2008-06-27 Last updated: 2010-04-23Bibliographically approved

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