The ethics as well as practices of the new genetics depend on the global context, but techno-science also changes in the face of emerging everyday dilemmas according to local conditions. The new project presented in this paper project intends to ascertain how the management of transgenic animals shapes and are shaped by, wider socio-cultural and techno-scientific change. We investigate the everyday handling in production of and experimentation with transgenic animals concerning the emergence and management of ethical, social and ecological dilemmas. Transgenic animals challenge well established boundaries and can thus be expected to give rise to new quandaries and concerns; about culture and nature, human and animal, risk and safety, innovation and organism, science and technology, just to mention some. The project also intends to analyse the expression and management of the somewhat paradoxical situation, that industrial as well as university based research increasingly require transgenic animals, and that the same intensified research contribute to a situation where the handling of the hybrid become more and more complex and problematic, both on a societal, cultural and a scientific level. This is due to the challenges to established species boundaries and worldviews that these animals present. The research problems are analysed in two different areas: The everyday, practical interaction between humans and non-humans in laboratory settings and at the institutional level of animal experimentation ethics committees and their members. The objectives are thus: 1) to explore and understand the processes through which novel natures frame and are framed by public and scientific perceptions and worldviews, in the case of transgenic animals in Sweden, and 2) through this knowledge be able to contribute to well informed decision making on different institutional levels.