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Measurements of chromogranin B can serve as a complement to chromogranin A
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. (Clinical Chemistry)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Njurmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi)
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2007 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 139, no 1-3, 80-83 p.Article in journal (Refereed) Published
Abstract [en]

Objective

CgA has been shown to be an excellent marker for neuroendocrine tumours. However, there are two major drawbacks with CgA measurements; elevated levels are common in patients with decreased renal function and in patients on treatment with proton pump inhibitors. These problems are not seen with CgB measurements. We have recently presented the development of 13 region-specific radioimmunoassays for measurements of CgB. A region-specific assay was identified, which measured higher concentrations of CgB than the other assays and seemed to be very useful as a marker for neuroendocrine tumours. The aim of the present study was therefore to further explore the diagnostic potential of this assay in the clinical management of patients with neuroendocrine tumours.

Methods

Measurements of CgB with two methods were compared with CgA in plasma samples from patients investigated for neuroendocrine tumours (N = 86), patients with decreased renal function (N = 35) and patients on treatment with proton pump inhibitors (N = 29).

Results

The diagnostic sensitivity for the new CgB assay was almost as good as that for CgA. Furthermore, with CgB measurements we could avoid the falsely elevated levels of CgA found in patients with decreased renal function and treatment with proton pump inhibitors.

Conclusions

We conclude that the new CgB assay can serve as a complement to CgA measurements as an important tumour marker for neuroendocrine tumours.

Place, publisher, year, edition, pages
2007. Vol. 139, no 1-3, 80-83 p.
Keyword [en]
Chromogranin A, Chromogranin B, Carcinoid tumours, Endocrine pancreatic tumours, Neuroendocrine, Renal function
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22175DOI: 10.1016/j.regpep.2006.10.008ISI: 000244767000011PubMedID: 17116339OAI: oai:DiVA.org:uu-22175DiVA: diva2:49948
Available from: 2007-03-01 Created: 2007-03-01 Last updated: 2017-12-07Bibliographically approved

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Stridsberg, MatsEriksson, BarbroFellström, BengtJanson, Eva Tiensuu

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