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Expression pattern of somatostatin receptor subtypes 1-5 in human skin: an immunohistochemical study of healthy subjects and patients with psoriasis or atopic dermatitis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
2006 (English)In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 15, no 12, 950-957 p.Article in journal (Refereed) Published
Abstract [en]

In psoriasis and atopic dermatitis, the inflammatory events have neurogenic components and the neuropeptides modify the functions of immuno-active cells in the skin. Somatostatin is a neuropeptide with several neuroendocrine and immunomodulating properties and mediates its actions by five distinct subtypes of G-protein-coupled receptors (SSTR1-5). This study describes the distribution of SSTR1-5, analysed with immunohistochemistry, in psoriasis, atopic dermatitis and controls. Normal human skin and lesional skin from patients with psoriasis or atopic dermatitis showed many similarities, but also some differences, as regards SSTR expression. SSTR1-3 were strongly expressed in the epidermis of healthy skin, and in the skin of patients with psoriasis or atopic dermatitis. It is noteworthy that SSTR4 and 5 were strongly expressed in the epidermis of psoriasis patients, but weakly expressed in the epidermis of those with atopic dermatitis and normal skin. The intensity of the staining also varied considerably between the different layers of the epidermis, especially in psoriasis patients. In all cases, the dendritic cells, found mostly in the papillary and upper reticular dermis, showed a strong expression of SSTR1-4, but a weak expression of SSTR5. SSTR1-5 were strongly expressed in the sweat glands in all skin biopsies. Hair follicles and sebaceous glands expressed all five subtypes. Striated muscle fibres showed an intense positive expression of SSTR1-4, but a weak or negative expression of SSTR5. The wide distribution and expression pattern of all five SSTRs in human skin suggest that somatostatin is involved in the interactions between the nervous system and the skin.

Place, publisher, year, edition, pages
2006. Vol. 15, no 12, 950-957 p.
Keyword [en]
atopic dermatitis, immunohistochemistry, neuropeptides, psoriasis, somatostatin receptors
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22177DOI: 10.1111/j.1600-0625.2006.00487.xISI: 000241766500002PubMedID: 17083361OAI: oai:DiVA.org:uu-22177DiVA: diva2:49950
Available from: 2007-01-23 Created: 2007-01-23 Last updated: 2017-12-07

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Stridsberg, Mats

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