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Interactions between heparan sulfate and proteins: the concept of specificity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2006 (English)In: Journal of Cell Biology, ISSN 0021-9525, E-ISSN 1540-8140, Vol. 174, no 3, 323-327 p.Article, review/survey (Refereed) Published
Abstract [en]

Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS-protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.

Place, publisher, year, edition, pages
2006. Vol. 174, no 3, 323-327 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22328PubMedID: 16880267OAI: oai:DiVA.org:uu-22328DiVA: diva2:50101
Available from: 2007-01-16 Created: 2007-01-16 Last updated: 2017-12-07Bibliographically approved

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Kreuger, JohanSpillmann, DorotheLi, Jin-pingLindahl, Ulf

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