Interactions between heparan sulfate and proteins: the concept of specificity
2006 (English)In: Journal of Cell Biology, ISSN 0021-9525, E-ISSN 1540-8140, Vol. 174, no 3, 323-327 p.Article, review/survey (Refereed) Published
Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS-protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.
Place, publisher, year, edition, pages
2006. Vol. 174, no 3, 323-327 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-22328PubMedID: 16880267OAI: oai:DiVA.org:uu-22328DiVA: diva2:50101