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Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2006 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 34, no Pt 3, 454-455 p.Article in journal (Refereed) Published
Abstract [en]

HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. it has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.

Place, publisher, year, edition, pages
2006. Vol. 34, no Pt 3, 454-455 p.
Keyword [en]
extracellular matrix, growth factor, heparan sulphate, pericyte recruitment, plateletderived growth factor (PDGF), retention motif
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22330ISI: 000238630000031PubMedID: 16709185OAI: oai:DiVA.org:uu-22330DiVA: diva2:50103
Available from: 2007-01-16 Created: 2007-01-16 Last updated: 2017-12-07Bibliographically approved

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Li, Jin-PingLindahl, UlfKjellén, LenaSpillmann, Dorothe

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