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Double-functionalized nanopore-embedded gold electrodes for rapid DNA sequencing
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
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2012 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 100, no 2, 023701- p.Article in journal (Refereed) Published
Abstract [en]

We have studied the effect of double-functionalization on gold electrodes for improving nanopore-based DNA sequencing. The functionalizing molecular probes are, respectively, capable of temporarily forming hydrogen bonds with both the nucleobase part and the phosphate group of the target DNA, thus potentially minimizing the structural fluctuations of a single-stranded DNA molecule passing between the gold electrodes. The results of our first-principles study indicate that the proposed setup yields current signals that differ by at least 1 order of magnitude for the four different nucleic acid bases, thus offering the possibility to electrically distinguish them.

Place, publisher, year, edition, pages
2012. Vol. 100, no 2, 023701- p.
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Physical Sciences
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URN: urn:nbn:se:uu:diva-168591DOI: 10.1063/1.3673335ISI: 000299126800091OAI: oai:DiVA.org:uu-168591DiVA: diva2:501539
Available from: 2012-02-14 Created: 2012-02-13 Last updated: 2017-12-07Bibliographically approved

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Pathak, BiswarupLöfås, HenrikPrasongkit, JariyaneeGrigoriev, AntonAhuja, RajeevScheicher, Ralph H.

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