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The transcriptome of the adenovirus infected cell
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk farmakologi och informatik)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk farmakologi och informatik)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
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2012 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 424, no 2, 115-128 p.Article in journal (Refereed) Published
Abstract [en]

Alternations of cellular gene expression following an adenovirus type 2 infection of human primary cells were studied by using superior sensitive cDNA sequencing. In total, 3791 cellular genes were identified as differentially expressed more than 2-fold. Genes involved in DNA replication, RNA transcription and cell cycle regulation were very abundant among the up-regulated genes. On the other hand, genes involved in various signaling pathways including TGF-β, Rho, G-protein, Map kinase, STAT and NF-κB stood out among the down-regulated genes. Binding sites for E2F, ATF/CREB and AP2 were prevalent in the up-regulated genes, whereas binding sites for SRF and NF-κB were dominant among the down-regulated genes. It is evident that the adenovirus has gained a control of the host cell cycle, growth, immune response and apoptosis at 24h after infection. However, efforts from host cell to block the cell cycle progression and activate an antiviral response were also observed.

Place, publisher, year, edition, pages
2012. Vol. 424, no 2, 115-128 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-168669DOI: 10.1016/j.virol.2011.12.006ISI: 000300752900004PubMedID: 22236370OAI: oai:DiVA.org:uu-168669DiVA: diva2:502115
Available from: 2012-02-14 Created: 2012-02-14 Last updated: 2017-12-07Bibliographically approved

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Zhao, HongxingDahlö, MartinIsaksson, AndersSyvänen, Ann-ChristinePettersson, Ulf

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