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Macrolide resistance can be transferred by conjugation from viridans streptococci to Streptococcus pyogenes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2006 (English)In: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 28, no 2, 101-103 p.Article in journal (Refereed) Published
Abstract [en]

Efflux pumps encoded by mef genes are among the most common mechanisms of resistance to macrolides. These genes are often located on horizontally transferable elements such as transposons. We present data indicating conjugative transfer of the mef(E) gene from viridans streptococci to the pathogen Streptococcus pyogenes. The mef(E) gene is located on the previously described MEGA (macrolide efflux genetic assembly) element. Of 110 isolates tested, 85% of those that carried the mef(A/E) gene carried it on MEGA, and in all cases of conjugal transfer of the mef(E) gene it was carried on MEGA. It therefore appears reasonable to draw the conclusion that this element is important in the lateral transfer of macrolide resistance between streptococci.

Place, publisher, year, edition, pages
2006. Vol. 28, no 2, 101-103 p.
Keyword [en]
macrolide resistance, conjugation, viridans streptococci, Streptococcus pyogenes, mef(A/E)
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22540DOI: 10.1016/j.ijantimicag.2006.02.023ISI: 000240372800004PubMedID: 16844354OAI: oai:DiVA.org:uu-22540DiVA: diva2:50313
Available from: 2007-01-18 Created: 2007-01-18 Last updated: 2017-12-07Bibliographically approved

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