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The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Clinical pharmacogenetics and Osteoporosis)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Metabolic Bone Diseases)
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2006 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 39, no 6, 1343-1351 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. METHODS: We therefore conducted a study in 230 men aged 41-76 years of age. BMD was measured with DXA. A second bone scan was performed on average 2.7 years after the first investigation. Dietary habits were assessed by 14 dietary 24-h recall interviews. The polyadenosine (A) VDR genotypes were determined. RESULTS: Dietary vitamin D intake was associated with BMD at all sites, also after multivariate adjustment. Those in the highest quintile of intake had 9% higher femoral neck BMD (p = 0.004), 6% higher BMD at the lumbar spine (p = 0.06) and 5% higher total body BMD (p = 0.003) compared to men in the lowest quintile of dietary vitamin D intake. However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). There was furthermore a trend, in the lumbar spine, of less reduction in BMD with increasing vitamin D intake (p = 0.07) but not at the other sites. Calcium intake conferred no association with BMD. CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction.

Place, publisher, year, edition, pages
2006. Vol. 39, no 6, 1343-1351 p.
Keyword [en]
Bone mineral density, Vitamin D, Diet, VDR, Calcium, Polymorphism
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22627DOI: 10.1016/j.bone.2006.06.003ISI: 000243011900022PubMedID: 16860619OAI: oai:DiVA.org:uu-22627DiVA: diva2:50400
Available from: 2007-02-05 Created: 2007-02-05 Last updated: 2017-12-07Bibliographically approved

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Michaëlsson, KarlJacobsson, AnnicaKindmark, AndreasStiger, FredrikMallmin, HansLjunghall, SverkerMelhus, Håkan

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