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Disease Extent ≥4 cm Is a Prognostic Marker of Local Recurrence in T1-2 Breast Cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Center for Clinical Research Dalarna.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Center for Clinical Research Dalarna. (Reproduktiv hälsa/Sundström Poromaa)
Department of Pathology and Clinical Cytology, Central Hospital Falun, Sweden.
2011 (English)In: Pathology research international, ISSN 2042-003XArticle in journal (Refereed) Published
Abstract [en]

Despite improvements of the therapy for breast cancer, a proportion of the patients still get local recurrence. The status of the surgical margins is the most often used parameter for decision regarding additional treatment. However, a negative margin is not a guarantee that there is not residual cancer left in the breast; additional parameters are needed to better predict the risk of local recurrence. The disease extent was evaluated in the surgical specimen from 313 women after breast-conserving therapy using large-section histology and was correlated to the incidence of local recurrence. A disease extent ≥4 cm was shown to be an independent marker for local recurrence; the cumulative 10-year local relapse rate for the group with a disease extent ≥4 cm was 20.5%, and for the rest 6.7%. We conclude that disease extent ≥4 cm seems to be an important factor when evaluating the risk for local recurrence.

Place, publisher, year, edition, pages
2011.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-168929DOI: 10.4061/2011/860584PubMedID: 21845209OAI: oai:DiVA.org:uu-168929DiVA: diva2:504220
Available from: 2012-02-20 Created: 2012-02-20 Last updated: 2012-02-20Bibliographically approved

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