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Nucleic acid therapeutics for hematologic malignancies--theoretical considerations
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Bioorganic Chemistry.
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2006 (English)In: OLIGONUCLEOTIDE THERAPEUTICS / [ed] Tuschl T; Rossi J, 2006, Vol. 1082, 124-136 p.Conference paper, Published paper (Refereed)
Abstract [en]

Our work is motivated by the belief that RNA targeted gene silencing agents can be developed into effective drugs for treating hematologic malignancies. In many experimental systems, antisense nucleic acids of various composition, including antisense oligodeoxynucleotides (AS ODNs) and short interfering RNA (siRNA), have been shown to perturb gene expression in a sequence specific manner. Nevertheless, our clinical experience, and those of others, have led us to conclude that the antisense nucleic acids (ASNAs) we, and others, employ need to be optimized with regard to intracellular delivery, targeting, chemical composition, and efficiency of mRNA destruction. We have hypothesized that addressing these critical issues will lead to the development of practical and effective nucleic acid drugs. An overview of our recent work which seeks to addresses these core issues is contained within this review.

Place, publisher, year, edition, pages
2006. Vol. 1082, 124-136 p.
Series
Annals of the New York Academy of Sciences, ISSN 0077-8923 ; 1082
Keyword [en]
leukemia, lymphoma, antisense, oligonucleotides
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-22692DOI: 10.1196/annals.1348.002ISI: 000243449900017PubMedID: 17145934ISBN: 978-157331587-6 (print)OAI: oai:DiVA.org:uu-22692DiVA: diva2:50465
Conference
1st Annual Meeting of the Oligonucleotide-Therapeutics-Society New York, NY, 2005
Available from: 2007-05-08 Created: 2007-05-08 Last updated: 2011-04-12Bibliographically approved

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