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How selective sweeps in domestic animals provide new insight into biological mechanisms
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2012 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 271, no 1, 1-14 p.Article, review/survey (Refereed) Published
Abstract [en]

Genetic studies of domestic animals are of general interest because there is more phenotypic diversity to explore in these species than in any experimental organism. Some mutations with favourable phenotypic effects have been highly enriched and gone through selective sweeps during the process of domestication and selective breeding. Three such selective sweeps are described in this review. All three mutations are intronic and constitute cis-acting regulatory mutations. Two of the mutations constitute structural changes (one duplication and one copy number expansion). These examples illustrate a general trend that noncoding mutations and structural changes have both contributed significantly to the evolution of phenotypic diversity in domestic animals. How the molecular characterization of trait loci in domestic animals can provide new basic knowledge of relevance for human medicine is discussed.

Place, publisher, year, edition, pages
2012. Vol. 271, no 1, 1-14 p.
Keyword [en]
comparative genomics, intronic mutations, regulatory mutations, structural variation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-169137DOI: 10.1111/j.1365-2796.2011.02450.xISI: 000298582800001PubMedID: 21895806OAI: oai:DiVA.org:uu-169137DiVA: diva2:505092
Available from: 2012-02-23 Created: 2012-02-23 Last updated: 2012-02-28Bibliographically approved

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