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Bioluminescence imaging of energy depletion in vascular pathology: patent ductus arteriosus and atherosclerosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg.
2012 (English)In: Journal of Biophotonics, ISSN 1864-0648, Vol. 5, no 4, 336-344 p.Article in journal (Refereed) Published
Abstract [en]

The artery wall may develop energy depletion due to insufficient nutritional supply. However, until recently it has not been possible to validate this hypothesis because no available technology has allowed assessment of energy metabolism with sufficient spatial resolution. We use high resolution bioluminescence metabolic imaging to study energy metabolism in two mechanistically different vascular pathologies: patent ductus arteriosus and atherosclerosis. Physiological energy depletion in postnatally constricting ductus arteriosus promotes permanent closure. Insufficient ductus energy depletion, common in preterm infants, is associated with persistent patent ductus arteriosus, a condition with significantly increased morbidity and mortality. In contrast, in atherosclerosis, energy depletion in the macrophage-rich lesion core promotes cell death contributing to lesion instability and disease progression.

Place, publisher, year, edition, pages
2012. Vol. 5, no 4, 336-344 p.
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-169449DOI: 10.1002/jbio.201100096ISI: 000302071900008PubMedID: 22134948OAI: oai:DiVA.org:uu-169449DiVA: diva2:506756
Available from: 2012-02-29 Created: 2012-02-29 Last updated: 2012-05-09Bibliographically approved

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