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Ticke-borne encephalitis is associated with low levels of interleukin-10 in cerebrospinal fluid
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
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2011 (English)In: Infection Ecology & Epidemiology, ISSN 2000-8686, Vol. 1, 6029- p.Article in journal (Refereed) Published
Abstract [en]

Tick-borne encephalitis (TBE) is associated with higher morbidity and induces a stronger intrathecal immune activation than most other viral induced meningo-encephalitis. The aim of this study was to investigate cytokine concentrations in cerebrospinal fluid (CSF) and serum in relation to aetiology and clinical course. Cytokines were analysed by Enzyme-linked Immuno Assay (ELISA) from 44 patients with TBE and from 36 patients with aseptic meningo-encephalitis of other aetiology (non-TBE). Significantly increased CSF levels of Interferon-γ (IFN-γ), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1 receptor antagonist (IL- 1ra), and soluble CD8 receptor (sCD8) were detected in both cohorts. Tumour necrosis factor-α (TNF-α showed low levels or was not detected in CSF in any group in the acute stage. However, the CSF levels of IL- 10 were significantly lower in TBE than in non-TBE cases 06 days after onset of encephalitis. The TBE patients with encephalitis had significantly lower IL-10 CSF levels later in the clinical course (day 718) than TBE patients with meningeal disease. Increased IFN-γ production, but low IL-10 secretion, may be of pathophysiological significance in TBE.

Place, publisher, year, edition, pages
2011. Vol. 1, 6029- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-169475DOI: 10.3402/iee.v1i0.6029OAI: oai:DiVA.org:uu-169475DiVA: diva2:506852
Available from: 2012-03-01 Created: 2012-03-01 Last updated: 2012-04-11Bibliographically approved

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Günther, Göran
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