T Regulatory Cells in B-Cell Malignancy: Tumor Support or Kiss of Death?
2012 (English)In: Immunology, ISSN 0019-2805, E-ISSN 1365-2567, Vol. 135, no 4, 255-260 p.Article, review/survey (Refereed) Published
It is well established that T regulatory cells (Tregs) counteract tumor immunity. However, conflicting results describing the role of Tregs in hematological tumors warrant further investigations to clarify the interactions between Tregs and the tumor. B-cell malignancy derives from different stages of B-cell development and differentiation in which T-cells play a profound role. The transformed B-cell may still be in need of T-cell help to thrive but simultaneously they may be recognized and destroyed by cytotoxic lymphocytes. Recent reports demonstrate that Tregs can suppress and even kill B-cells as part of their normal function to rescue the body from autoimmunity. An emerging body of evidence points out that Tregs inhibit tumor-specific T-cells but may also have a role in suppressing the progression of the B-cell tumor. In this review, we discuss the origin and function of Tregs and their role in patients with B-cell tumors.
Place, publisher, year, edition, pages
2012. Vol. 135, no 4, 255-260 p.
B-cell leukaemia, B-cell lymphoma, cytotoxic regulatory cells, immune regulation, T regulatory cells
IdentifiersURN: urn:nbn:se:uu:diva-169485DOI: 10.1111/j.1365-2567.2011.03539.xISI: 000300982500001PubMedID: 22112044OAI: oai:DiVA.org:uu-169485DiVA: diva2:506923