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T Regulatory Cells in B-Cell Malignancy: Tumor Support or Kiss of Death?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2012 (English)In: Immunology, ISSN 0019-2805, E-ISSN 1365-2567, Vol. 135, no 4, 255-260 p.Article, review/survey (Refereed) Published
Abstract [en]

It is well established that T regulatory cells (Tregs) counteract tumor immunity. However, conflicting results describing the role of Tregs in hematological tumors warrant further investigations to clarify the interactions between Tregs and the tumor. B-cell malignancy derives from different stages of B-cell development and differentiation in which T-cells play a profound role. The transformed B-cell may still be in need of T-cell help to thrive but simultaneously they may be recognized and destroyed by cytotoxic lymphocytes. Recent reports demonstrate that Tregs can suppress and even kill B-cells as part of their normal function to rescue the body from autoimmunity. An emerging body of evidence points out that Tregs inhibit tumor-specific T-cells but may also have a role in suppressing the progression of the B-cell tumor. In this review, we discuss the origin and function of Tregs and their role in patients with B-cell tumors.

Place, publisher, year, edition, pages
2012. Vol. 135, no 4, 255-260 p.
Keyword [en]
B-cell leukaemia, B-cell lymphoma, cytotoxic regulatory cells, immune regulation, T regulatory cells
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-169485DOI: 10.1111/j.1365-2567.2011.03539.xISI: 000300982500001PubMedID: 22112044OAI: oai:DiVA.org:uu-169485DiVA: diva2:506923
Available from: 2012-03-01 Created: 2012-03-01 Last updated: 2017-12-07Bibliographically approved

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Lindqvist, Camilla ALoskog, Angelica Si

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