uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The 7-year cumulative incidence of cornea guttata and morphological changes in the corneal endothelium in the Reykjavik Eye Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Neuroscience Research, University of Akureyri, Akureyri, Iceland.
Dept. of Ophthalmology, Kanazawa Medical University, Uchinada, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Show others and affiliations
2013 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 91, no 3, 212-218 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To examine the corneal endothelium and establish the 7-year cumulativeincidence of cornea guttata (CG).

Methods: Population-based prospective cohort study with 573 participants(third wave of the Reykjavik Eye Study (RES) in 2008). Four hundred and thirty-seven subjects had either right or left eyes available for analysis after excluding confounding eye conditions. The baseline for eyes at risk for developing CG is the second wave of the RES in 2001. Participants underwent specular microscopy and a standardized eye examination.

Results: The cumulative 7-year incidence of CG in either eye was estimated as a 95% confidence interval for the expected value for both genders combined (15–23%), for males (8–18%) and for females (19–29%). In right eye only, the 7-year cumulative incidence for both genders combined was estimated to be 6–11%. For genders combined and for males only, the data indicated no correlation between 7-year cumulated incidence and age at baseline. In women, however, the change of 7-year incidence for CG in at least one eye appeared to be correlated to age at baseline. Reduction of endothelial cell density for corneas with CG at baseline was found [CI (0.95))132 ± 94].

Conclusion: The cumulative 7-year incidence of primary central CG for a middle-aged and older Caucasian population without history of potentially confounding eye disease has been established. Women tend to have higher incidence if onset occurs at middle age. If CG is present, the cell density and the cell size variation decrease within a 7-year period.

Place, publisher, year, edition, pages
2013. Vol. 91, no 3, 212-218 p.
Keyword [en]
cornea guttata, endothelium, incidence, morphology, population based, specular microscopy
National Category
Research subject
URN: urn:nbn:se:uu:diva-169659DOI: 10.1111/j.1755-3768.2011.02360.xISI: 000317983000024OAI: oai:DiVA.org:uu-169659DiVA: diva2:507512
Available from: 2012-03-05 Created: 2012-03-05 Last updated: 2013-06-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Zoega, Gunnar MarSöderberg, Per
By organisation
In the same journal
Acta Ophthalmologica

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link