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Positron Emitting [Ga-68]Ga-Based Imaging Agents: Chemistry and Diversity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences.
2011 (English)In: Medicinal Chemistry, ISSN 1573-4064, Vol. 7, no 5, 345-379 p.Article, review/survey (Refereed) Published
Abstract [en]

Positron Emission Tomography (PET) field and, in particular utilization of Ga-68 radiometal is getting momentum. The development of new imaging agents for targeted, pre-targeted, non-targeted imaging and their clinical applications is accelerating worldwide. The pharmacopoeia monographs regarding generator produced Ga-68 radionuclide and Ga-68-labeled somatostatin (SST) analogues are in progress. The number of commercial generators and automated synthesizers for Ga-68-labeling chemistry is increasing constantly. Development of a molecular imaging agent is a complex process including identification of the biological target, respective lead compound, synthesis of the imaging agent, its chemical characterization, pre-clinical, and clinical evaluation. The introduction of new radiopharmaceuticals and their accessibility are important factors determining the expansion of clinical nuclear medicine for early disease detection and personalized medicine with higher therapeutic efficiency. Further, the availability of the technology for GMP compliant automated tracer production can facilitate the introduction of new radiopharmaceuticals due to the ability to conduct standardized and harmonized multi-center studies for regulatory approval. This review reflects on the current status of Ga-68 in PET field with the focus on the achievements in the chemistry as well as diversity and potential of the resulting tracers.

Place, publisher, year, edition, pages
2011. Vol. 7, no 5, 345-379 p.
Keyword [en]
Positron emission tomography, Ga-68, radiochemistry, coordination chemistry, conjugation chemistry
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-169629DOI: 10.2174/157340611796799195ISI: 000299575500003OAI: oai:DiVA.org:uu-169629DiVA: diva2:507522
Available from: 2012-03-05 Created: 2012-03-05 Last updated: 2015-03-25Bibliographically approved

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Velikyan, Irina
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