Cystatin C as a marker of immune complex-associated renal impairment in a sudanese population with visceral leishmaniasis
2006 (English)In: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, Vol. 75, no 5, 864-868 p.Article in journal (Refereed) Published
Renal function was studied in visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL) by means of the specific marker cystatin C and related to circulating immune complexes and cytokine production. Forty patients with VL (23 with sub-acute disease and 17 with acute disease), 17 patients with PKDL, and 22 healthy controls were included. Cystatin C, but not creatinine, was significantly raised in VL (P = 0.004). The highest levels of cystatin C were found in those with acute disease (P < 0.0001). In VL, cystatin C levels were positively correlated to circulating immune complexes and production of granulocyte-macrophage colony stimulating factor (GM-CSF), but negatively correlated to aspartate aminotransferase and lactate dehydrogenase. We conclude that cystatin C is a superior marker of glomerular function in leishmaniasis and that immune complex deposition and GM-CSF are two functions that most likely are causally involved in the mechanisms leading to glomerular dysfunction in leishmaniasis.
Place, publisher, year, edition, pages
2006. Vol. 75, no 5, 864-868 p.
Other Clinical Medicine Immunology in the medical area
IdentifiersURN: urn:nbn:se:uu:diva-22998ISI: 000242189100016PubMedID: 17123978OAI: oai:DiVA.org:uu-22998DiVA: diva2:50771