uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Show others and affiliations
2012 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 23, no 4, 948-954 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To determine whether the change in tumor diameters at the first follow-up computed tomography (CT) examination after baseline examination (first change) correlates with outcome in patients with metastatic colorectal cancer (mCRC) treated with combination chemotherapy.

PATIENTS AND METHODS: The first change was analyzed in a multicenter randomized phase III trial (Nordic VI, N = 567) comparing first-line irinotecan with either bolus or infused 5-fluorouracil. Cox proportional hazards multiple regression model and Kaplan-Meier survival analyses after correction for guarantee-time bias were carried out to evaluate correlations between first change, objective response according to RECIST 1.0, progression-free survival (PFS), and overall survival (OS).

RESULTS: The hazard ratios for PFS and OS decreased along with first change. A decrease between 10% and <30%, albeit RECIST does not regard this as a partial response, was a positive prognostic factor for PFS and OS. Patients who had new lesions or unequivocal progression of nonmeasurable lesions had a worse prognosis than those with only an increase in size of >20%.

CONCLUSIONS: The change in tumor size at the first follow-up CT is strongly prognostic for PFS and OS in mCRC.

Place, publisher, year, edition, pages
2012. Vol. 23, no 4, 948-954 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-169860DOI: 10.1093/annonc/mdr350ISI: 000302298000020PubMedID: 21832285OAI: oai:DiVA.org:uu-169860DiVA: diva2:507860
Available from: 2012-03-06 Created: 2012-03-06 Last updated: 2014-09-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sundin, AndersByström, PerBerglund, ÅkeNygren, PeterGlimelius, Bengt
By organisation
In the same journal
Annals of Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 392 hits
ReferencesLink to record
Permanent link

Direct link